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CS-W001157 4
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3-Methylquinolin-2-amine

  • CAS No. 74844-99-8

  • Cat. No. CS-0322491
  • Molecule weight158.20
  • Purity≥97%
  • MDL No.MFCD00272502

*For research and further manufacturing use only, not for direct human use.

3-Methylquinolin-2-amine|CS-0322491

Structure of 74844-99-8

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General Information

  • CAS No. 74844-99-8
  • Cat. No. CS-0322491
  • Purity ≥97%
  • MDL No. MFCD00272502
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂
  • Molecular Weight 158.20
  • Synonym(s) None
  • SMILES CC1=CC2=C(C=CC=C2)N=C1N

Description

3-Methylquinolin-2-amine features a quinoline scaffold with a methyl group at the 3-position and an amino functionality at the 2-position, delivering enhanced electron density and improved solubility in polar solvents. This structural configuration supports efficient integration into pharmaceutical intermediates and ligand design, particularly in metal-catalyzed coupling reactions where steric and electronic modulation are critical.

Application

3-Methylquinolin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through standard functional group transformations. Its inherent stability and compatibility with palladium-catalyzed cross-coupling reactions facilitate the construction of complex heterocycles. The molecule functions effectively as a nitrogen donor in transition metal catalysis and supports direct arylation or alkylation protocols, offering practical utility in synthetic routes to bioactive compounds.

Synthesis

  • Route1

    References

    • Korodi Synthetic Communications, 1991 , vol. 21, # 18-19 p. 1841 - 1846
  • Route2
    • null|null
      74845-05-9
    • ~%
    • In-stock
      3-Methylquinolin-2-amine|CS-0322491
      74844-99-8

    References

    • Journal of Organic Chemistry, , vol. 45, # 23 p. 4767 - 4769
  • Route3
    • null|null
      1873-55-8
    • ~%
    • In-stock
      3-Methylquinolin-2-amine|CS-0322491
      74844-99-8

    References

    • Journal of Organic Chemistry, , vol. 72, # 12 p. 4554 - 4557

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.12542
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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