4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid

Name: 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 74840-34-9
Cat. No. CS-0045703
Purity≥95%
MDL No.MFCD06643376

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid|CS-0045703

Structure of 74840-34-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 74840-34-9
Cat. No. CS-0045703
Purity ≥95%
MDL No. MFCD06643376
Storage -20°C, stored under nitrogen, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClN₂O₂S
Molecular Weight 204.63
Synonym(s) 4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid
SMILES O=C(C1=CN=C(SC)N=C1Cl)O

Description

4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid is a heterocyclic building block featuring a chlorine atom at C4, a methylthio group at C2, and a carboxylic acid at C5. This combination delivers enhanced electrophilicity and solubility in polar solvents, enabling efficient coupling reactions in medicinal chemistry applications. The molecule exhibits bench-stable handling under standard conditions.

Application

4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and coupling reactions. The chloro group facilitates C–N and C–C bond formation under standard conditions, while the carboxylic acid enables amide coupling or esterification for downstream derivatization. The methylthio substituent provides orthogonal reactivity and enhances metabolic stability in target molecules. Bench-stable and readily purified by recrystallization, it supports scalable synthesis of bioactive intermediates.

Synthesis

Route1
- 5909-24-0
- ~%
- In-stock
  
  74840-34-9
References
- US2008/114007 A1, ; Page/Page column 82 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 63.08
LogP 1.5501
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

74840-34-9 sigma74840-34-9 manufacturer74840-34-9 price74840-34-9 structure74840-34-9 SDSbuy 74840-34-974840-34-9 supplier74840-34-9 uses74840-34-9 molecular weightprice of 74840-34-974840-34-9 chemical name formula of 74840-34-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid

CAS No. 74840-34-9

Recommended Products