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CS-W001157 4
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(1-Methyl-1H-benzoimidazol-2-yl)-methanol

  • CAS No. 7467-35-8

  • Cat. No. CS-0021454
  • Purity≥97%
  • MDL No.MFCD00464051

*For research and further manufacturing use only, not for direct human use.

(1-Methyl-1H-benzoimidazol-2-yl)-methanol|CS-0021454

Structure of 7467-35-8

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General Information

  • CAS No. 7467-35-8
  • Cat. No. CS-0021454
  • Purity ≥97%
  • MDL No. MFCD00464051
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀N₂O
  • Molecular Weight 162.19
  • Synonym(s) 1-Methyl-2-hydroxymethylbenzimidazole; 2-Hydroxymethyl-1-methyl-1H-benzimidazole; NSC 400948; (1-methyl-1H-benzimidazol-2-yl)methanol
  • SMILES OCC1=NC2=CC=CC=C2N1C

Description

This bench-stable benzimidazole derivative features a methyl-substituted heterocyclic core paired with a reactive hydroxymethyl group. The functionalized side chain enables direct incorporation into bioconjugation workflows and modular synthesis of pharmaceutical intermediates, offering enhanced solubility in polar solvents and compatibility with standard coupling conditions.

Application

(1-Methyl-1H-benzoimidazol-2-yl)-methanol serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds. Its benzimidazole core provides enhanced metabolic stability and favorable pharmacophore properties, while the pendant alcohol functions as a handle for derivatization via esterification, ether formation, or oxidation. The compound exhibits good bench stability and is compatible with standard purification methods, facilitating integration into medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry, , vol. 14, # 19 p. 6695 - 6712
  • Route2

    References

    • Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 18, # 12 p. 1299 - 1302 Khimiya Geterotsiklicheskikh Soedinenii, , vol. 18, # 12 p. 1679 - 1681
  • Route3
    • In-stock
      2-Benzimidazolemethanol|CS-0019195
      4856-97-7
    • null|null
      74-88-4
    • ~89%
    • In-stock
      (1-Methyl-1H-benzoimidazol-2-yl)-methanol|CS-0021454
      7467-35-8

    References

    • Bulletin of the Korean Chemical Society, , vol. 34, # 4 p. 1272 - 1274

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.0656
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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