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CS-W001157 4
Total: USD 88.00

m-PEG3-Amine

  • CAS No. 74654-07-2

  • Cat. No. CS-W018960
  • Purity≥95%
  • MDL No.MFCD17215909

*For research and further manufacturing use only, not for direct human use.

m-PEG3-Amine|CS-W018960

Structure of 74654-07-2

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General Information

  • CAS No. 74654-07-2
  • Cat. No. CS-W018960
  • Purity ≥95%
  • MDL No. MFCD17215909
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₇NO₃
  • Molecular Weight 163.21
  • Synonym(s) None
  • SMILES COCCOCCOCCN

Description

m-PEG3-Amine features a central amine functionality flanked by two ethylene glycol units, delivering enhanced solubility and stability in aqueous environments. This bifunctional scaffold enables efficient conjugation in bioconjugation workflows, particularly for peptide and protein derivatization under mild conditions.

Application

m-PEG3-Amine serves as a versatile bifunctional linker for conjugation and polymer chemistry, offering three ethylene glycol units for enhanced solubility and reduced non-specific binding. The terminal primary amine enables straightforward coupling with carboxylic acids, aldehydes, or activated esters, facilitating the synthesis of bioconjugates, PEGylated compounds, and functionalized surfaces. Its bench-stable nature and ease of purification make it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      167221-50-3
    • ~85%
    • In-stock
      m-PEG3-Amine|CS-W018960
      74654-07-2

    References

    • Lowicki, Daniel; Huczynski, Adam; Brzezinski, Bogumil; Bartl, Franz Journal of Molecular Structure, 2011 , vol. 990, # 1-3 p. 121 - 131
  • Route2

    References

    • Schmidt, Manfred; Amstutz, Rene; Crass, Gerhard; Seebach, Dieter Chemische Berichte, 1980 , vol. 113, # 5 p. 1691 - 1707
  • Route3

    References

    • Clerc, Jerome; Schellenberg, Barbara; Groll, Michael; Bachmann, Andre S.; Huber, Robert; Dudler, Robert; Kaiser, Markus European Journal of Organic Chemistry, 2010 , # 21 p. 3991 - 4003

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.71
  • LogP   -0.3753
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   8

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