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CS-W001157 4
Total: USD 88.00

2-(4-Chlorophenyl)-2-fluoroacetic acid

  • CAS No. 74590-69-5

  • Cat. No. CS-0104537
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(4-Chlorophenyl)-2-fluoroacetic acid|CS-0104537

Structure of 74590-69-5

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General Information

  • CAS No. 74590-69-5
  • Cat. No. CS-0104537
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆ClFO₂
  • Molecular Weight 188.58
  • Synonym(s) p-chlorophenylfluoroacetic acid
  • SMILES O=C(O)C(F)C1=CC=C(Cl)C=C1

Description

2-(4-Chlorophenyl)-2-fluoroacetic acid features a fluorinated acetic acid core substituted with a chlorophenyl group, delivering enhanced metabolic stability and lipophilicity. This structural motif enables direct incorporation into bioactive scaffolds for medicinal chemistry applications. The compound exhibits robust bench stability and facilitates efficient derivatization under standard conditions.

Application

2-(4-Chlorophenyl)-2-fluoroacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic compounds through established carboxylation and functional group transformation protocols. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient access to bioactive scaffolds, particularly in CNS-targeted drug discovery where halogenated aryl motifs are prevalent.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.4352
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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