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CS-W001157 4
Total: USD 88.00

3-Bromo-4-chloroquinoline

  • CAS No. 74575-17-0

  • Cat. No. CS-0096780
  • Purity≥97%
  • MDL No.MFCD05738886

*For research and further manufacturing use only, not for direct human use.

3-Bromo-4-chloroquinoline|CS-0096780

Structure of 74575-17-0

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General Information

  • CAS No. 74575-17-0
  • Cat. No. CS-0096780
  • Purity ≥97%
  • MDL No. MFCD05738886
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅BrClN
  • Molecular Weight 242.50
  • Synonym(s) Quinoline,3-bromo-4-chloro
  • SMILES ClC1=C(Br)C=NC2=CC=CC=C12

Description

3-Bromo-4-chloroquinoline is a halogenated quinoline derivative featuring complementary reactive sites for cross-coupling and functionalization. This electron-deficient heterocycle integrates readily into synthetic scaffolds requiring precise regiocontrol, offering robust stability under standard conditions.

Application

3-Bromo-4-chloroquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the chloro moiety offers orthogonal functionalization potential. Its stability under standard reaction conditions and compatibility with diverse synthetic transformations make it ideal for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P280-P330-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.6507
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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