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CS-W001157 4
Total: USD 88.00

3-Maleimidopropionic acid

  • CAS No. 7423-55-4

  • Cat. No. CS-W019611
  • Molecule weight169.13
  • Purity≥97%
  • MDL No.MFCD00043030

*For research and further manufacturing use only, not for direct human use.

3-Maleimidopropionic acid|CS-W019611

Structure of 7423-55-4

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General Information

  • CAS No. 7423-55-4
  • Cat. No. CS-W019611
  • Purity ≥97%
  • MDL No. MFCD00043030
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₄
  • Molecular Weight 169.13
  • Synonym(s) None
  • SMILES O=C(O)CCN1C(C=CC1=O)=O

Description

N-Maleoyl--alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.N-Maleoyl--alanine (3-maleimidopropanoic acid, N-(2-carboxyethyl)maleimide)) is the suitable reagent used in the following studies:To decrease the biotin binding affinity of Avd(S16C) (avidin with a single point mutation S16C).As a side chain reactive agent to modify tryptic peptides that result in mass shifts indicating the presence of cysteine residues.To preblock Xenopus laevis oocytes for exposed cysteines used as an expression system in the study of conformational changes in cASIC1a Receptors.It may be used in the following studies:As a protective agent for keratin fiber in high temperature process.As a non-cleavable maleimido moiety during the synthesis of tetrawalled molecular umbrella-octaarginine conjugates.Synthesis of organotin carboxylates of N-Maleoyl--alanine.To functionalize the gold surfaces to interact with cysteine-modified peptide.Preparation of cross-linked dextranpoly(ethylene glycol) hydrogel substrate.

Synthesis

  • Route1
    • null|null
      108-31-6
    • In-stock
      β-Alanine|CS-W020126
      107-95-9
    • ~83%
    • In-stock
      3-Maleimidopropionic acid|CS-W019611
      7423-55-4

    References

    • Han, Jing; Sun, Lidan; Chu, Yingying; Li, Zheng; Huang, Dandan; Zhu, Xiaoyun; Qian, Hai; Huang, Wenlong Journal of Medicinal Chemistry, 2013 , vol. 56, # 24 p. 9955 - 9968
  • Route2
    • (2Z)-4-[(2-Carboxyethyl)amino]-4-oxo-2-butenoic acid|CS-1135884
      57079-11-5
    • ~12%
    • In-stock
      3-Maleimidopropionic acid|CS-W019611
      7423-55-4

    References

    • Veprek, Pavel; Hajduch, Marian; Dzubak, Petr; Kuklik, Rostislav; Polakova, Jana; Bezouska, Karel Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6400 - 6407
  • Route3
    • null|null
      108-31-6
    • null|null
      64-19-7
    • In-stock
      β-Alanine|CS-W020126
      107-95-9
    • ~48%
    • In-stock
      3-Maleimidopropionic acid|CS-W019611
      7423-55-4

    References

    • Yang, Hai-Kuan; Su, Ming-Ming; Ren, Li-Jun; Tang, Jing; Yan, Yu-Kun; Miao, Wen-Ke; Zheng, Ping; Wang, Wei European Journal of Inorganic Chemistry, 2013 , # 8 p. 1381 - 1389

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   74.68
  • LogP   -0.6139
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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