3'-NH2-ddA

Name: 3'-NH2-ddA
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CAS No. 7403-25-0
Cat. No. CS-W012644
Molecule weight250.26
Purity≥98%
MDL No.MFCD08703999

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 7403-25-0

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General Information

CAS No. 7403-25-0
Cat. No. CS-W012644
Purity ≥98%
MDL No. MFCD08703999
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₄N₆O₂
Molecular Weight 250.26
Synonym(s) 3'-Amino-2',3'-dideoxyadenosine
SMILES OC[C@@H]1[C@@H](N)C[C@H](N2C(N=CN=C3N)=C3N=C2)O1

Description

This nucleoside analog features a tetrahydrofuran sugar moiety with stereochemistry at the 2S,3S,5R positions, enabling precise incorporation into oligonucleotide synthesis. The pendant amino group and purine base facilitate hydrogen bonding in duplex structures, while the primary alcohol supports efficient derivatization. Bench-stable under standard conditions, it serves as a key building block for modified DNA/RNA constructs.

Application

((2S,3S,5R)-3-Amino-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol serves as a key nucleoside scaffold building block, enabling efficient synthesis of purine-based analogs. Its tetrahydrofuran core provides stereochemical control and enhanced stability, while the amino and hydroxymethyl functionalities offer versatile handles for phosphorylation, glycosylation, and coupling reactions. The molecule exhibits robust bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns targeting antiviral and anticancer agents.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 125.1
LogP -0.9844
H_Acceptors 8
H_Donors 3
Rotatable_Bonds 2

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3'-NH2-ddA

CAS No. 7403-25-0

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