3'-NH2-ddA

Name: 3'-NH2-ddA
Brand: ChemScene
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CAS No. 7403-25-0
Cat. No. CS-W012644
Purity≥98%
MDL No.MFCD08703999

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 7403-25-0

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Description

This nucleoside analog features a tetrahydrofuran sugar moiety with stereochemistry at the 2S,3S,5R positions, enabling precise incorporation into oligonucleotide synthesis. The pendant amino group and purine base facilitate hydrogen bonding in duplex structures, while the primary alcohol supports efficient derivatization. Bench-stable under standard conditions, it serves as a key building block for modified DNA/RNA constructs.

Application

((2S,3S,5R)-3-Amino-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol serves as a key nucleoside scaffold building block, enabling efficient synthesis of purine-based analogs. Its tetrahydrofuran core provides stereochemical control and enhanced stability, while the amino and hydroxymethyl functionalities offer versatile handles for phosphorylation, glycosylation, and coupling reactions. The molecule exhibits robust bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns targeting antiviral and anticancer agents.

General Information

CAS No. 7403-25-0
Cat. No. CS-W012644
Purity ≥98%
MDL No. MFCD08703999
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₄N₆O₂
Molecular Weight 250.26
Synonym(s) 3'-Amino-2',3'-dideoxyadenosine
SMILES OC[C@@H]1[C@@H](N)C[C@H](N2C(N=CN=C3N)=C3N=C2)O1

Computational Chemistry Data

TPSA 125.1
LogP -0.9844
H_Acceptors 8
H_Donors 3
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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3'-NH2-ddA

CAS No. 7403-25-0

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