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CS-W001157 4
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(2,4-Diaminopteridin-6-yl)methanol hydrochloride

  • CAS No. 73978-41-3

  • Cat. No. CS-W008143
  • Purity≥97%
  • MDL No.MFCD00191246

*For research and further manufacturing use only, not for direct human use.

(2,4-Diaminopteridin-6-yl)methanol hydrochloride|CS-W008143

Structure of 73978-41-3

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General Information

  • CAS No. 73978-41-3
  • Cat. No. CS-W008143
  • Purity ≥97%
  • MDL No. MFCD00191246
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉ClN₆O
  • Molecular Weight 228.64
  • Synonym(s) 2,4-diamino-6-(hydroxymethyl)-pteridine hydrochloride
  • SMILES NC(N1)=C2C(N=CC(CO)=N2)=NC1=N.Cl

Application

(2,4-Diaminopteridin-6-yl)methanol hydrochloride serves as a versatile building block for the synthesis of pteridine-based scaffolds, enabling efficient access to functionalized heterocycles relevant in medicinal chemistry. The compound exhibits robust bench stability and facilitates straightforward derivatization via nucleophilic substitution or coupling reactions, with excellent solubility in common organic solvents. Its dual amine functionality supports orthogonal protection strategies, while the methanol group provides a handle for further functionalization, making it well-suited for parallel library synthesis and API development workflows.

Synthesis

  • Route1

    References

    • Boyle, Peter H.; Pfleiderer, Wolfgang Chemische Berichte, 1980 , vol. 113, # 4 p. 1514 - 1523
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 28, # 5 p. 660 - 667

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   124.56
  • LogP   -0.67133
  • H_Acceptors   6
  • H_Donors   4
  • Rotatable_Bonds   1

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