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CS-W001157 4
Total: USD 88.00

4-(2,6-Dichlorophenyl)thiazol-2-amine

  • CAS No. 736901-08-9

  • Cat. No. CS-0695342
  • Molecule weight245.13
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(2,6-Dichlorophenyl)thiazol-2-amine|CS-0695342

Structure of 736901-08-9

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General Information

  • CAS No. 736901-08-9
  • Cat. No. CS-0695342
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆Cl₂N₂S
  • Molecular Weight 245.13
  • Synonym(s) None
  • SMILES NC1=NC(=CS1)C1=C(Cl)C=CC=C1Cl

Description

4-(2,6-Dichlorophenyl)thiazol-2-amine features a thiazole core bearing a 2,6-dichlorophenyl substituent, delivering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in kinase inhibitors and antiparasitic agents.

Application

4-(2,6-Dichlorophenyl)thiazol-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiazole-based scaffolds with enhanced metabolic stability. Its dual electron-withdrawing dichlorophenyl and amine-functionalized thiazole moieties facilitate coupling reactions and offer robust bench stability. The compound functions effectively in Pd-catalyzed cross-couplings and serves as a key intermediate in the development of bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   3.6991
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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