4-Chloro-6-(propan-2-yl)pyrimidin-2-amine

Name: 4-Chloro-6-(propan-2-yl)pyrimidin-2-amine
Brand: ChemScene
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CAS No. 73576-33-7
Cat. No. CS-0037473
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-Chloro-6-(propan-2-yl)pyrimidin-2-amine|CS-0037473

Structure of 73576-33-7

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General Information

CAS No. 73576-33-7
Cat. No. CS-0037473
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀ClN₃
Molecular Weight 171.63
Synonym(s) 4-chloro-6-isopropyl-pyrimidin-2-amine
SMILES NC1=NC(C(C)C)=CC(Cl)=N1

Description

4-Chloro-6-(propan-2-yl)pyrimidin-2-amine is a bench-stable, moisture-tolerant pyrimidine derivative featuring a chlorine substituent at C4 and a bulky isopropyl group at C6. This substitution pattern enhances electronic modulation and steric shielding, enabling direct incorporation into kinase inhibitors and other bioactive scaffolds via palladium-catalyzed cross-coupling reactions under standard conditions.

Application

4-Chloro-6-(propan-2-yl)pyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chloro group facilitates Suzuki-Miyaura and Buchwald-Hartwig couplings, while the pendant amine supports derivatization and salt formation. The isopropyl substituent enhances lipophilicity and metabolic stability, offering favorable physicochemical properties for drug discovery applications.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 51.8
LogP 1.8356
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Chloro-6-(propan-2-yl)pyrimidin-2-amine

CAS No. 73576-33-7

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