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CS-W001157 4
Total: USD 88.00

2-Chloroquinoline-3-carbaldehyde

  • CAS No. 73568-25-9

  • Cat. No. CS-W015838
  • Purity≥97%
  • MDL No.MFCD00130079

*For research and further manufacturing use only, not for direct human use.

2-Chloroquinoline-3-carbaldehyde|CS-W015838

Structure of 73568-25-9

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General Information

  • CAS No. 73568-25-9
  • Cat. No. CS-W015838
  • Purity ≥97%
  • MDL No. MFCD00130079
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆ClNO
  • Molecular Weight 191.61
  • Synonym(s) None
  • SMILES ClC1=NC2=CC=CC=C2C=C1C=O

Description

2-Chloroquinoline-3-carbaldehyde features a chlorinated quinoline core with an aldehyde handle at the 3-position, enabling direct integration into heterocyclic synthesis. The electron-deficient aromatic system enhances reactivity in nucleophilic additions and condensation reactions. This bench-stable compound serves as a key intermediate for pharmaceuticals and functional materials.

Application

2-Chloroquinoline-3-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient access to quinoline-based scaffolds. Its aldehyde functionality supports standard transformations including reductive amination, Grignard additions, and Wittig reactions, while the ortho-chloro substituent facilitates palladium-catalyzed coupling processes. The compound exhibits good bench stability and is readily purified by column chromatography, making it well-suited for multi-step synthesis workflows.

Synthesis

  • Route1
    • null|null
      68-12-2
    • null|null
      103-84-4
    • ~90%
    • In-stock
      2-Chloroquinoline-3-carbaldehyde|CS-W015838
      73568-25-9

    References

    • Ali; Tasneem; Rajanna; Sai Prakash Synlett, 2001 , # 2 p. 251 - 253
  • Route2

    References

    • North Carolina State University Patent: US5162532 A1, 1992 ;
  • Route3
    • null|null
      103-84-4
    • ~75%
    • In-stock
      2-Chloroquinoline-3-carbaldehyde|CS-W015838
      73568-25-9

    References

    • North Carolina State University Patent: US5162532 A1, 1992 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.7007
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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