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CS-W001157 4
Total: USD 88.00

(E)-3-(2,3-Dimethoxyphenyl)acrylic acid

  • CAS No. 7345-82-6

  • Cat. No. CS-W015228
  • Purity≥95%
  • MDL No.MFCD00004376

*For research and further manufacturing use only, not for direct human use.

(E)-3-(2,3-Dimethoxyphenyl)acrylic acid|CS-W015228

Structure of 7345-82-6

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General Information

  • CAS No. 7345-82-6
  • Cat. No. CS-W015228
  • Purity ≥95%
  • MDL No. MFCD00004376
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₄
  • Molecular Weight 208.21
  • Synonym(s) trans-3-(2,3-Dimethoxyphenyl)-2-propenoic Acid
  • SMILES O=C(O)/C=C/C1=CC=CC(OC)=C1OC

Description

Fmoc-Val-Ala-PAB is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Fmoc group can be deprotected under basic conditions to obtain the free amine which can be used for further conjugations.

Synthesis

  • Route1

    References

    • Jardon, Phillip W.; Vickery, Euin H.; Pahler, Leon F.; Pourahmady, Naser; Mains, Gilbert J.; Eisenbraun, Edmund J. Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2130 - 2135
  • Route2

    References

    • Russian Journal of General Chemistry, , vol. 75, # 7 p. 1113 - 1124

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.8016
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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