Lot numbers can be found on the outside label of a product:
1-Methyl-5-nitro-1H-indazol-3-amine
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CAS No. 73105-48-3
- Cat. No. CS-0042591
- Purity≥98%
- MDL No.MFCD16619579
*For research and further manufacturing use only, not for direct human use.
Structure of 73105-48-3
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General Information
- CAS No. 73105-48-3
- Cat. No. CS-0042591
- Purity ≥98%
- MDL No. MFCD16619579
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₈N₄O₂
- Molecular Weight 192.17
- Synonym(s) 1-Methyl-5-nitroindazol-3-amine
- SMILES NC1=NN(C)C2=C1C=C([N+]([O-])=O)C=C2
Description
1-Methyl-5-nitro-1H-indazol-3-amine features a fused bicyclic core bearing a nitro group at C5 and a methylated amine at C3, delivering enhanced electron deficiency and improved metabolic stability. This configuration supports efficient integration into kinase inhibitor scaffolds and facilitates coupling reactions under mild conditions.
Application
1-Methyl-5-nitro-1H-indazol-3-amine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to indazole-based scaffolds prevalent in medicinal chemistry. Its nitro group facilitates subsequent reduction and coupling reactions, while the amino functionality supports direct derivatization. The molecule exhibits bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in API development.
Synthesis
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Route1
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In-stock
17417-09-3 -
60-34-4 - ~94%
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In-stock
73105-48-3
References
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Liu, Han-Jun; Hung, Shiang-Fu; Chen, Chuan-Lin; Lin, Mei-Huey Tetrahedron, 2013 , vol. 69, # 19 p. 3907 - 3912
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Route2
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In-stock
5228-49-9 - ~15%
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In-stock
73105-48-3
References
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Bouchet, P.; Lazaro, R.; Benchidmi, M.; Elguero, J. Tetrahedron, 1980 , vol. 36, p. 3523 - 3534
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Route3
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74209-24-8 - ~21%
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In-stock
73105-48-3
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77894-78-1
References
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Bouchet, P.; Lazaro, R.; Benchidmi, M.; Elguero, J. Tetrahedron, 1980 , vol. 36, p. 3523 - 3534
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 86.98
- LogP 1.0637
- H_Acceptors 5
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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