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Structure of 731002-60-1
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2-Chloro-6-(trifluoromethyl)pyridin-3-ol features a trifluoromethyl group at the pyridine ring's 6-position, enhancing electron deficiency and metabolic stability. The ortho-chloro and phenolic hydroxyl groups enable direct coupling in cross-coupling reactions or serve as anchors for further functionalization. This bench-stable scaffold integrates efficiently into bioactive molecules and advanced materials.
2-Chloro-6-(trifluoromethyl)pyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring due to its orthogonal reactivity profile. The chloro group facilitates palladium-catalyzed cross-coupling reactions, while the phenolic hydroxyl supports derivatization or metal complexation. Its stability under standard bench conditions and compatibility with diverse reaction environments make it ideal for constructing bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: