7-Chloro-1,2,3,4-tetrahydroisoquinoline;hydrochloride

Name: 7-Chloro-1,2,3,4-tetrahydroisoquinoline;hydrochloride
Brand: ChemScene
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CAS No. 73075-45-3
Cat. No. CS-0036914
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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7-Chloro-1,2,3,4-tetrahydroisoquinoline;hydrochloride|CS-0036914

Structure of 73075-45-3

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General Information

CAS No. 73075-45-3
Cat. No. CS-0036914
Purity ≥97%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₁Cl₂N
Molecular Weight 204.10
Synonym(s) 7-chloro-1,2,3,4-tetrahydroisoquinoline HCl salt
SMILES C1=C2CCNCC2=CC(=C1)Cl.Cl

Description

7-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a chlorinated aromatic ring fused to a saturated nitrogen-containing backbone. This compound integrates readily into medicinal chemistry scaffolds, where the electron-deficient pyridine-like core enhances binding affinity in target-directed synthesis. The hydrochloride salt improves solubility and handling in aqueous reaction media.

Application

7-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride serves as a well-established building block for the synthesis of bioactive heterocycles, enabling efficient access to isoquinoline-based scaffolds prevalent in medicinal chemistry. Its amine functionality facilitates straightforward derivatization via alkylation, acylation, and reductive amination, while the chloride salt enhances solubility and stability in aqueous and polar organic media. The compound exhibits robust bench stability and compatibility with standard purification techniques, making it ideal for use in multi-step synthetic sequences targeting CNS-active compounds and kinase inhibitors.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.03
LogP 2.4075
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Tetrahydroisoquinoline compounds

Key Words

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7-Chloro-1,2,3,4-tetrahydroisoquinoline;hydrochloride

CAS No. 73075-45-3

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