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CS-W001157 4
Total: USD 88.00

4-(Chloromethyl)-1,2-dimethoxybenzene

  • CAS No. 7306-46-9

  • Cat. No. CS-0199523
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Chloromethyl)-1,2-dimethoxybenzene|CS-0199523

Structure of 7306-46-9

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General Information

  • CAS No. 7306-46-9
  • Cat. No. CS-0199523
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁ClO₂
  • Molecular Weight 186.64
  • Synonym(s) Veratryl chloride
  • SMILES COC1=C(C=C(C=C1)CCl)OC

Description

4-(Chloromethyl)-1,2-dimethoxybenzene features a chloromethyl group flanked by two methoxy substituents, delivering enhanced electrophilicity and stability. This configuration enables direct functionalization in synthetic sequences, particularly in the construction of aromatic scaffolds for pharmaceutical intermediates and agrochemicals.

Application

4-(Chloromethyl)-1,2-dimethoxybenzene serves as a versatile benzylating agent in synthetic organic chemistry, enabling efficient introduction of the (chloromethyl)phenyl motif under mild conditions. The ortho-dimethoxy substitution enhances electrophilic reactivity while providing stability and ease of purification. It functions reliably in nucleophilic substitution reactions, particularly in the construction of heterocyclic scaffolds and medicinal chemistry intermediates, with broad functional group tolerance and predictable regioselectivity.

Synthesis

  • Route1

    References

    • Nisshin Flour Milling Co., Ltd. Patent: US5736550 A1, 1998 ;
  • Route2

    References

    • US4937246 A1, ;
  • Route3
    • null|null
      108-48-5
    • In-stock
      (2,3-Dimethoxyphenyl)methanol|CS-Z0027
      5653-67-8
    • ~%
    • null|null
      3893-01-4
    • In-stock
      4-(Chloromethyl)-1,2-dimethoxybenzene|CS-0199523
      7306-46-9

    References

    • US4342780 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.4426
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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