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CS-W001157 4
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N-(3-Acetyl-4-hydroxyphenyl)acetamide

  • CAS No. 7298-67-1

  • Cat. No. CS-0154123
  • Purity≥98%
  • MDL No.MFCD00100490

*For research and further manufacturing use only, not for direct human use.

N-(3-Acetyl-4-hydroxyphenyl)acetamide|CS-0154123

Structure of 7298-67-1

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General Information

  • CAS No. 7298-67-1
  • Cat. No. CS-0154123
  • Purity ≥98%
  • MDL No. MFCD00100490
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₃
  • Molecular Weight 193.20
  • Synonym(s) 3'-Acetyl-4'-hydroxyacetanilide
  • SMILES CC(C1=C(O)C=CC(NC(C)=O)=C1)=O

Description

N-(3-Acetyl-4-hydroxyphenyl)acetamide features a phenolic hydroxyl group flanked by an acetyl and acetamide substituent, offering enhanced solubility and stability in aqueous and organic media. This scaffold integrates readily into bioactive molecule synthesis, particularly for kinase inhibitors and anti-inflammatory agents. The para-positioned hydroxyl enables hydrogen bonding, while the acetyl moiety provides metabolic resistance.

Application

N-(3-Acetyl-4-hydroxyphenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive phenolic scaffolds. The acetyl and hydroxyl groups provide orthogonal functional handles for selective derivatization, while the amide linkage ensures stability under standard synthetic conditions. Its bench-stable nature and compatibility with common coupling and protection strategies facilitate streamlined synthesis of complex heterocycles and drug candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   1.5532
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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