2-Amino-2-(4-fluorophenyl)acetic acid

Name: 2-Amino-2-(4-fluorophenyl)acetic acid
Brand: ChemScene
Availability: InStock
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CAS No. 7292-73-1
Cat. No. CS-0128891
Purity≥98%
MDL No.MFCD00066444

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Amino-2-(4-fluorophenyl)acetic acid|CS-0128891

Structure of 7292-73-1

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Description

2-Amino-2-(4-fluorophenyl)acetic acid features a sterically unhindered alpha-amino carboxylic acid scaffold with a para-fluorinated aryl group, enabling direct incorporation into peptide architectures. The electron-withdrawing fluorine enhances metabolic stability while maintaining solubility under standard reaction conditions. This building block facilitates the synthesis of bioactive analogs in medicinal chemistry campaigns targeting CNS and oncology applications.

Application

2-Amino-2-(4-fluorophenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of arylglycine derivatives through standard peptide coupling and functionalization protocols. Its fluorinated aromatic moiety enhances metabolic stability and modulates electronic properties, while the α-amino carboxylic acid functionality facilitates direct incorporation into bioactive scaffolds. The compound exhibits good bench stability and is compatible with common purification methods, supporting scalable access to pharmaceutically relevant intermediates.

General Information

CAS No. 7292-73-1
Cat. No. CS-0128891
Purity ≥98%
MDL No. MFCD00066444
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈FNO₂
Molecular Weight 169.15
Synonym(s) DL-4-Fluorophenylglycine
SMILES O=C(O)C(N)C1=CC=C(F)C=C1

Computational Chemistry Data

TPSA 63.32
LogP 0.9101
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Amino Acids and their Derivatives Alanine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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2-Amino-2-(4-fluorophenyl)acetic acid

CAS No. 7292-73-1

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