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CS-W001157 4
Total: USD 88.00

1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde

  • CAS No. 728034-12-6

  • Cat. No. CS-W008755
  • Purity≥95%
  • MDL No.MFCD08272237

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde|CS-W008755

Structure of 728034-12-6

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General Information

  • CAS No. 728034-12-6
  • Cat. No. CS-W008755
  • Purity ≥95%
  • MDL No. MFCD08272237
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) 1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde
  • SMILES O=CC1=C2C(NC=C2)=NC=C1

Description

1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde delivers a rigid, electron-deficient heteroaromatic scaffold ideal for constructing advanced pharmaceutical intermediates. The aldehyde functionality enables direct coupling in Ullmann or Buchwald-Hartwig reactions, while the fused pyrrolopyridine core enhances metabolic stability and target affinity in kinase inhibitor design.

Application

1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its aldehyde functionality enables efficient derivatization via reductive amination, Wittig reactions, and coupling protocols. The scaffold exhibits excellent bench stability and compatibility with common protecting groups, facilitating modular synthesis of complex polycycles and bioactive molecules.

Synthesis

  • Route1

    References

    • US2004/186124 A1, ; Page/Page column 14 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   1.3754
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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