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Structure of 72587-18-9
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2-Chloro-5-(trifluoromethyl)pyridin-3-amine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the chloro and amine functionalities enable diverse coupling reactions. This pyridine derivative serves as a key intermediate in pharmaceutical synthesis, particularly for kinase inhibitors and agrochemicals.
2-Chloro-5-(trifluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the primary amine facilitates further functionalization. This compound exhibits excellent bench stability and compatibility with standard synthetic workflows, making it a reliable scaffold for constructing bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: