tert-Butyl (3R,4R)-4-amino-3-methylpiperidine-1-carboxylate

Name: tert-Butyl (3R,4R)-4-amino-3-methylpiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 723308-58-5
Cat. No. CS-0100337
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3R,4R)-4-amino-3-methylpiperidine-1-carboxylate|CS-0100337

Structure of 723308-58-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 723308-58-5
Cat. No. CS-0100337
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₂N₂O₂
Molecular Weight 214.30
Synonym(s) 2-Methyl-2-propanyl (3R,4R)-4-amino-3-methyl-1-piperidinecarboxyl ate
SMILES O=C(N1C[C@@H](C)[C@H](N)CC1)OC(C)(C)C

Description

tert-Butyl (3R,4R)-4-amino-3-methylpiperidine-1-carboxylate features a stereochemically defined piperidine core with a bench-stable tert-butyl carbamate protecting group. This configuration enables direct incorporation into chiral scaffolds for medicinal chemistry, where the primary amine and methyl substituent offer precise spatial control for target engagement.

Application

tert-Butyl (3R,4R)-4-amino-3-methylpiperidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of bioactive piperidine derivatives. Its tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the 4-amino functionality enables direct functionalization in amide couplings or reductive amination sequences. The (3R,4R) configuration ensures predictable stereochemical outcomes in downstream transformations, making it ideal for medicinal chemistry applications requiring precise control over molecular architecture.

Synthesis

Route1
- 3886-69-9
- ~90%
- In-stock
  
  723308-58-5
References
- MILLENNIUM PHARMACEUTICALS, INC. Patent: WO2004/58709 A1, 2004 ; Location in patent: Page 31; 37 ; WO 2004/058709 A1
Route2
- 723308-56-3
- ~89%
- In-stock
  
  723308-58-5
References
- MILLENNIUM PHARMACEUTICALS, INC. Patent: WO2004/58736 A1, 2004 ; Location in patent: Page 26; 32 ; WO 2004/058736 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 2735
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 55.56
LogP 1.5906
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

723308-58-5 sigma723308-58-5 manufacturer723308-58-5 price723308-58-5 structure723308-58-5 SDSbuy 723308-58-5723308-58-5 supplier723308-58-5 uses723308-58-5 molecular weightprice of 723308-58-5723308-58-5 chemical name formula of 723308-58-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

tert-Butyl (3R,4R)-4-amino-3-methylpiperidine-1-carboxylate

CAS No. 723308-58-5

Recommended Products