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CS-W001157 4
Total: USD 88.00

5-Bromoquinolin-4-ol

  • CAS No. 723283-89-4

  • Cat. No. CS-0041977
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromoquinolin-4-ol|CS-0041977

Structure of 723283-89-4

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General Information

  • CAS No. 723283-89-4
  • Cat. No. CS-0041977
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆BrNO
  • Molecular Weight 224.05
  • Synonym(s) 5-Bromo-4-quinolinol
  • SMILES OC1=CC=NC2=CC=CC(Br)=C12

Description

5-Bromoquinolin-4-ol integrates a bromine substituent at the 5-position and a hydroxyl group at the 4-position of the quinoline scaffold, delivering a rigid, electron-deficient heteroaromatic system. This configuration enhances reactivity in palladium-catalyzed cross-coupling processes while maintaining stability under standard handling conditions. The molecule's polarity supports solubility in common organic solvents, enabling seamless incorporation into synthetic workflows for pharmaceutical intermediates and functional materials.

Application

5-Bromoquinolin-4-ol serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality and phenolic hydroxyl group. The molecule exhibits bench stability and facilitates efficient derivatization in late-stage functionalization, particularly in the construction of biologically relevant quinoline scaffolds. Its dual reactivity profile—bromine for coupling and hydroxyl for protection or substitution—supports orthogonal transformations in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.7029
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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