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Structure of 72235-58-6
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This bench-stable arylamine features a strategically positioned chloro and fluorine substituent, enabling selective functionalization in medicinal chemistry. The para-fluorine enhances metabolic stability while the ortho-chloro group directs electrophilic substitution, making this scaffold valuable for constructing bioactive heterocycles under standard conditions.
(4-Chloro-3-fluorophenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated arylamines through established coupling and functionalization protocols. Its ortho-halogenated aromatic core provides enhanced reactivity in palladium-catalyzed cross-couplings, while the primary amine facilitates straightforward derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in API development and target-oriented synthesis.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 2735
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H227-H314
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Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: