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CS-W001157 4
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(4-Chloro-3-fluorophenyl)methanamine

  • CAS No. 72235-58-6

  • Cat. No. CS-0062988
  • Purity≥97%
  • MDL No.MFCD04116008

*For research and further manufacturing use only, not for direct human use.

(4-Chloro-3-fluorophenyl)methanamine|CS-0062988

Structure of 72235-58-6

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General Information

  • CAS No. 72235-58-6
  • Cat. No. CS-0062988
  • Purity ≥97%
  • MDL No. MFCD04116008
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClFN
  • Molecular Weight 159.59
  • Synonym(s) 4-Chloro-3-Fluorobenzyl Amine
  • SMILES NCC1=CC=C(Cl)C(F)=C1

Description

This bench-stable arylamine features a strategically positioned chloro and fluorine substituent, enabling selective functionalization in medicinal chemistry. The para-fluorine enhances metabolic stability while the ortho-chloro group directs electrophilic substitution, making this scaffold valuable for constructing bioactive heterocycles under standard conditions.

Application

(4-Chloro-3-fluorophenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated arylamines through established coupling and functionalization protocols. Its ortho-halogenated aromatic core provides enhanced reactivity in palladium-catalyzed cross-couplings, while the primary amine facilitates straightforward derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in API development and target-oriented synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P403-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.9378
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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