1-(Prop-2-yn-1-yl)pyrrolidine

Name: 1-(Prop-2-yn-1-yl)pyrrolidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 7223-42-9
Cat. No. CS-0058395
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(Prop-2-yn-1-yl)pyrrolidine|CS-0058395

Structure of 7223-42-9

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General Information

CAS No. 7223-42-9
Cat. No. CS-0058395
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₁N
Molecular Weight 109.17
Synonym(s) None
SMILES C#CCN1CCCC1

Description

1-(Prop-2-yn-1-yl)pyrrolidine is a versatile pyrrolidine derivative featuring a terminal alkyne group, enabling efficient conjugation via copper-catalyzed click chemistry. This functional handle integrates readily into bioconjugates and small-molecule libraries, offering high reactivity under mild conditions. The molecule exhibits excellent stability and solubility in common organic solvents, facilitating straightforward handling in synthetic workflows.

Application

1-(Prop-2-yn-1-yl)pyrrolidine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The terminal alkyne moiety facilitates reliable click chemistry transformations, while the pyrrolidine nitrogen provides a handle for further derivatization. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for medicinal chemistry applications and modular scaffold construction.

Synthesis

Route1
- 123-75-1
- 106-96-7
- ~86%
- In-stock
  
  7223-42-9
References
- CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin Patent: WO2013/97773 A1, 2013 ; Location in patent: Paragraph 0199; 0317 ;
Route2
- 123-75-1
- 75-09-2
- 75-20-7
- ~77%
- In-stock
  
  7223-42-9
References
- Lin, Zhewang; Yu, Dingyi; Sum, Yin Ngai; Zhang, Yugen ChemSusChem, 2012 , vol. 5, # 4 p. 625 - 628
Route3
- 154554-68-4
- ~%
- In-stock
  
  7223-42-9
- 134-84-9
References
- Unterhalt; Middelberg Pharmazie, 1994 , vol. 49, # 7 p. 492 - 494

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS05,GHS07
Signal Word : Danger	UN#: 2924
Class : 3,8	Packing Group : Ⅲ
Hazard Statements : H225-H302-H312-H314-H332
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 3.24
LogP 0.7154
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Alkyne

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Key Words

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1-(Prop-2-yn-1-yl)pyrrolidine

CAS No. 7223-42-9

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