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CS-W001157 4
Total: USD 88.00

2-(4-Fluorophenyl)pyrrolidine

  • CAS No. 72216-06-9

  • Cat. No. CS-0001894
  • Molecule weight165.21
  • Purity≥95%
  • MDL No.MFCD02663411

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluorophenyl)pyrrolidine|CS-0001894

Structure of 72216-06-9

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General Information

  • CAS No. 72216-06-9
  • Cat. No. CS-0001894
  • Purity ≥95%
  • MDL No. MFCD02663411
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂FN
  • Molecular Weight 165.21
  • Synonym(s) Pyrrolidine, 2-(4-fluorophenyl)-
  • SMILES FC1=CC=C(C=C1)C2NCCC2

Description

2-(4-Fluorophenyl)pyrrolidine is a bench-stable, electron-rich heterocyclic scaffold featuring a fluorinated aryl moiety that enhances metabolic stability and membrane permeability. This structural motif integrates seamlessly into bioactive molecules, serving as a key pharmacophore in CNS-targeted drug discovery and synthetic intermediates for functionalized pyrrolidines.

Application

2-(4-Fluorophenyl)pyrrolidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard functionalization of the pyrrolidine nitrogen and aromatic ring. Its bench-stable nature, combined with good solubility and tolerance to common reaction conditions, facilitates straightforward incorporation into diverse heterocyclic systems and drug-like molecules.

Synthesis

  • Route1
    • p-Fluorobenzenecarboxaldehyde Atorvastatin calcium|CS-0214005
      459-57-4
    • ~%
    • In-stock
      2-(4-Fluorophenyl)pyrrolidine|CS-0001894
      72216-06-9

    References

    • Journal of Organic Chemistry, , vol. 70, # 9 p. 3705 - 3708
  • Route2
    • 5-(4-Fluorophenyl)-3,4-dihydro-2H-pyrrole|CS-1161024
      22217-86-3
    • ~%
    • In-stock
      2-(4-Fluorophenyl)pyrrolidine|CS-0001894
      72216-06-9

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 4 p. 1436 - 1439

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.2502
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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