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CS-W001157 4
Total: USD 88.00

2-Acetamidobutanoic acid

  • CAS No. 7211-57-6

  • Cat. No. CS-0120033
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Acetamidobutanoic acid|CS-0120033

Structure of 7211-57-6

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General Information

  • CAS No. 7211-57-6
  • Cat. No. CS-0120033
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO₃
  • Molecular Weight 145.16
  • Synonym(s) 2-Acetamidobutyric Acid
  • SMILES CCC(NC(C)=O)C(O)=O

Description

2-Acetamidobutanoic acid features a β-amino acid scaffold with a pendant acetamide group, enabling direct incorporation into peptide-based systems. The molecule exhibits enhanced solubility and stability under physiological conditions, facilitating use in synthetic biology workflows and bioconjugation applications.

Application

2-Acetamidobutanoic acid serves as a versatile building block in peptide synthesis and medicinal chemistry, offering a stable β-amino acid scaffold with orthogonal functionalization potential. Its acetamide group enables hydrogen bonding and improves solubility, while the carboxylic acid facilitates coupling reactions under standard conditions. The molecule exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for modular synthesis of bioactive compounds and heterocyclic intermediates.

Synthesis

  • Route1
    • null|null
      108-24-7
    • In-stock
      H-DL-Abu-OH|CS-W011306
      2835-81-6
    • ~98%
    • In-stock
      2-Acetamidobutanoic acid|CS-0120033
      7211-57-6

    References

    • BAYER AKTIENGESELLSCHAFT; NIEWOeHNER, Maria, Theresia Patent: WO2003/97645 A1, 2003 ; Location in patent: Page/Page column 26 ;
  • Route2
    • In-stock
      Acetamide|CS-0015934
      60-35-5
    • null|null
      201230-82-2
    • null|null
      107-18-6
    • ~63%
    • In-stock
      2-Acetamidobutanoic acid|CS-0120033
      7211-57-6

    References

    • Hirai, Kenji; Fujita, Makoto; Fuchikami, Takamasa Journal of Organometallic Chemistry, 1985 , vol. 279, p. 203 - 214
  • Route3
    • N-(Prop-2-en-1-yl)acetamide|CS-0224602
      692-33-1
    • ~39%
    • In-stock
      2-Acetamidobutanoic acid|CS-0120033
      7211-57-6

    References

    • Magnus, Philip; Slater, Martin Tetrahedron Letters, 1987 , vol. 28, # 25 p. 2829 - 2832

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   -0.0143
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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