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CS-W001157 4
Total: USD 88.00

2-Phenoxy-1-phenylethanone

  • CAS No. 721-04-0

  • Cat. No. CS-0156550
  • Purity≥98%
  • MDL No.MFCD00156689

*For research and further manufacturing use only, not for direct human use.

2-Phenoxy-1-phenylethanone|CS-0156550

Structure of 721-04-0

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General Information

  • CAS No. 721-04-0
  • Cat. No. CS-0156550
  • Purity ≥98%
  • MDL No. MFCD00156689
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂O₂
  • Molecular Weight 212.24
  • Synonym(s) Phenyl phenacyl ether
  • SMILES C1=CC=C(C=C1)C(=O)COC2=CC=CC=C2

Description

2-Phenoxy-1-phenylethanone features a benzoyl scaffold flanked by phenoxy and phenyl moieties, delivering enhanced solubility in aromatic solvents. This electron-deficient ketone integrates readily into synthetic routes targeting bioactive scaffolds, offering robust stability under standard bench conditions.

Application

2-Phenoxy-1-phenylethanone serves as a versatile synthetic building block for benzophenone-derived scaffolds, enabling efficient construction of biaryl and heterocyclic systems. Its ketone functionality supports standard transformations including reduction, nucleophilic addition, and enolate chemistry, while the phenoxy group offers moderate stability and compatibility with common reaction conditions. The molecule functions effectively in multi-step syntheses requiring orthogonal functionalization and is amenable to purification via recrystallization or column chromatography.

Synthesis

  • Route1
    • null|null
      70-11-1
    • null|null
      108-95-2
    • ~95%
    • In-stock
      2-Phenoxy-1-phenylethanone|CS-0156550
      721-04-0

    References

    • Nichols, Jason M.; Bishop, Lee M.; Bergman, Robert G.; Ellman, Jonathan A. Journal of the American Chemical Society, 2010 , vol. 132, # 36 p. 12554 - 12555
  • Route2
    • 2-Fluoro-1-phenylethanone|CS-0037091
      450-95-3
    • null|null
      108-95-2
    • ~63%
    • In-stock
      2-Phenoxy-1-phenylethanone|CS-0156550
      721-04-0

    References

    • Takeda Pharmaceutical Company Limited Patent: EP1688138 A1, 2006 ; Location in patent: Page/Page column 93-94 ; EP 1688138 A1
  • Route3
    • null|null
      945656-60-0
    • ~7%
    • null|null
      1013938-60-7
    • In-stock
      2-Phenoxy-1-phenylethanone|CS-0156550
      721-04-0

    References

    • Shen, Zengming; Khan, Hasan A.; Dong, Vy M. Journal of the American Chemical Society, 2008 , vol. 130, # 10 p. 2916 - 2917

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H411
Precautionary Statements : P264-P270-P273-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.9483
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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