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CS-W001157 4
Total: USD 88.00

2-Chloro-3,6-dimethylpyridine

  • CAS No. 72093-14-2

  • Cat. No. CS-0153457
  • Purity≥95%
  • MDL No.MFCD12400985

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3,6-dimethylpyridine|CS-0153457

Structure of 72093-14-2

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General Information

  • CAS No. 72093-14-2
  • Cat. No. CS-0153457
  • Purity ≥95%
  • MDL No. MFCD12400985
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClN
  • Molecular Weight 141.60
  • Synonym(s) Pyrazine,3-chloro-2,5-dimethyl-,1-oxide
  • SMILES CC1=C(Cl)N=C(C)C=C1

Description

2-Chloro-3,6-dimethylpyridine is a sterically hindered, electron-deficient heterocycle featuring strategically positioned methyl groups that enhance regioselectivity in cross-coupling reactions. This bench-stable scaffold enables efficient construction of complex pyridyl architectures under standard conditions.

Application

2-Chloro-3,6-dimethylpyridine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling efficient functionalization at the pyridine ring due to its activated halogen and electron-donating methyl groups. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate rapid access to substituted pyridine scaffolds common in pharmaceutical development.

Synthesis

  • Route1
    • In-stock
      2-Chloro 3-methylpyridine|CS-W011138
      18368-76-8
    • null|null
      74-88-4
    • ~59%
    • In-stock
      2-Chloro-3,6-dimethylpyridine|CS-0153457
      72093-14-2

    References

    • ASTRAZENECA AB; ASTEX THERAPEUTICS Patent: WO2006/65204 A1, 2006 ; Location in patent: Page/Page column 147; 149-150 ; WO 2006/065204 A1
  • Route2
    • null|null
      125014-90-6
    • ~83%
    • In-stock
      2-Chloro-3,6-dimethylpyridine|CS-0153457
      72093-14-2

    References

    • Shvekhgeimer, M.-G. A.; Kobrakov, K. I.; Sychev, S. S.; Promonenkov, V. K. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1989 , vol. 25, # 4 p. 428 - 433 Khimiya Geterotsiklicheskikh Soedinenii, 1989 , # 4 p. 514 - 519

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.35184
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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