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5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride

  • CAS No. 720720-96-7

  • Cat. No. CS-M3401
  • Purity≥95%
  • MDL No.MFCD25542379
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride|CS-M3401

Structure of 720720-96-7

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Description

This tetrahydrothiazolopyridine carboxylic acid hydrochloride features a rigid, electron-deficient heterocyclic core paired with a methyl substituent at the 5-position, enhancing metabolic stability. The carboxylic acid functionality enables direct conjugation or salt formation, while the hydrochloride form ensures improved solubility and handling under standard bench conditions.

Application

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling efficient access to thiazolopyridine scaffolds prevalent in kinase inhibitors and CNS-targeted agents. The carboxylic acid functionality facilitates direct coupling reactions, while the hydrochloride salt enhances solubility and bench stability. Its robust functional group tolerance supports diverse derivatization strategies in standard synthetic workflows.

General Information

  • CAS No. 720720-96-7
  • Cat. No. CS-M3401
  • Purity ≥95%
  • MDL No. MFCD25542379
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁ClN₂O₂S
  • Molecular Weight 234.70
  • Synonym(s) 5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride; 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride(for Edoxaban)
  • SMILES O=C(C(S1)=NC2=C1CN(C)CC2)O.[H]Cl

Computational Chemistry Data

  • TPSA   53.43
  • LogP   1.251
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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