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CS-W001157 4
Total: USD 88.00

Fmoc-Asp(OtBu)-OH

  • CAS No. 71989-14-5

  • Cat. No. CS-D1469
  • Purity≥98%
  • MDL No.MFCD00037131

*For research and further manufacturing use only, not for direct human use.

Fmoc-Asp(OtBu)-OH|CS-D1469

Structure of 71989-14-5

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General Information

  • CAS No. 71989-14-5
  • Cat. No. CS-D1469
  • Purity ≥98%
  • MDL No. MFCD00037131
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₅NO₆
  • Molecular Weight 411.45
  • Synonym(s) 4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate; Fmoc-L-Asp(OtBu)-OH
  • SMILES O=C(OC(C)(C)C)C[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-Asp(OtBu)-OH is a protected aspartic acid derivative designed for solid-phase peptide synthesis. The Fmoc group enables efficient orthogonal deprotection, while the OtBu side chain protection ensures stability during coupling steps. This amino acid variant integrates seamlessly into peptide chains under standard conditions, offering reliable incorporation and minimal epimerization.

Synthesis

  • Route1

    References

    • Nowshuddin, Shaik; Rao; Reddy, A. Ram Synthetic Communications, 2009 , vol. 39, # 11 p. 2022 - 2031
  • Route2

    References

    • Schoen, Istvan; Kisfaludy, Lajos Synthesis, 1986 , # 4 p. 303 - 305
  • Route3
    • In-stock
      L-Aspartic acid 4-tert-butyl ester|CS-W008777
      3057-74-7
    • null|null
      99503-04-5
    • ~62%
    • In-stock
      Fmoc-Asp(OtBu)-OH|CS-D1469
      71989-14-5

    References

    • Henklein, Peter; Heyne, Hans-Ulrich; Halatsch, Wolf-Rainer; Niedrich, Hartmut Synthesis, 1987 , # 2 p. 166 - 167

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   3.7101
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   6

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