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CS-W001157 4
Total: USD 88.00

3-(3,5-Dimethoxyphenyl)propionic acid

  • CAS No. 717-94-2

  • Cat. No. CS-W003065
  • Purity≥98%
  • MDL No.MFCD03425685

*For research and further manufacturing use only, not for direct human use.

3-(3,5-Dimethoxyphenyl)propionic acid|CS-W003065

Structure of 717-94-2

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General Information

  • CAS No. 717-94-2
  • Cat. No. CS-W003065
  • Purity ≥98%
  • MDL No. MFCD03425685
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₄O₄
  • Molecular Weight 210.23
  • Synonym(s) 3,5-Dimethoxyphenylpropionic acid
  • SMILES COc1cc(CCC(=O)O)cc(c1)OC

Description

For protein solubilization

Application

3-(3,5-Dimethoxyphenyl)propionic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive scaffolds through standard coupling and functionalization reactions. Its aromatic core with two methoxy groups provides enhanced solubility and metabolic stability, while the carboxylic acid functionality facilitates direct derivatization or incorporation into peptide-like structures. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it suitable for iterative synthetic campaigns in API development.

Synthesis

  • Route1
    • (E)-3-(3,5-Dimethoxyphenyl)acrylic acid|CS-0368600
      20767-04-8
    • ~97%
    • In-stock
      3-(3,5-Dimethoxyphenyl)propionic acid|CS-W003065
      717-94-2

    References

    • F. HOFFMANN-LA ROCHE AG Patent: WO2007/71348 A1, 2007 ; Location in patent: Page/Page column 87 ;
  • Route2

    References

    • BAYER PHARMACEUTICALS CORPORATION Patent: WO2004/11446 A1, 2004 ; Location in patent: Page 72 ;
  • Route3

    References

    • Organic Letters, , vol. 5, # 24 p. 4653 - 4656

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.721
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   5

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