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Benzyl (S)-2-formylpyrrolidine-1-carboxylate

  • CAS No. 71461-30-8

  • Cat. No. CS-0319523
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Benzyl (S)-2-formylpyrrolidine-1-carboxylate|CS-0319523

Structure of 71461-30-8

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General Information

  • CAS No. 71461-30-8
  • Cat. No. CS-0319523
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅NO₃
  • Molecular Weight 233.26
  • Synonym(s) (S)-2-Formyl-pyrrolidine-1-carboxylic acid benzyl ester
  • SMILES C1=CC=C(C=C1)COC(=O)N2CCC[C@H]2C=O

Description

Benzyl (S)-2-formylpyrrolidine-1-carboxylate features a chiral pyrrolidine core with a formyl group at the 2-position, enabling direct functionalization in asymmetric synthesis. The benzyl ester moiety offers enhanced stability and ease of handling under standard conditions. This configuration facilitates efficient incorporation into complex molecular architectures.

Application

Benzyl (S)-2-formylpyrrolidine-1-carboxylate serves as a chiral building block for asymmetric synthesis, enabling efficient access to pyrrolidine-based scaffolds. The formyl group facilitates direct functionalization via nucleophilic addition or imine formation, while the benzyl ester offers convenient deprotection under mild hydrogenolysis conditions. Its stereochemical integrity and bench stability support reliable use in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   1.9865
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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