5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine

Name: 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine
Brand: ChemScene
Availability: InStock
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CAS No. 7135-02-6
Cat. No. CS-0033788
Molecule weight163.18
Purity≥98%
MDL No.MFCD00227025

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine|CS-0033788

Structure of 7135-02-6

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General Information

CAS No. 7135-02-6
Cat. No. CS-0033788
Purity ≥98%
MDL No. MFCD00227025
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₉N₅
Molecular Weight 163.18
Synonym(s) NSC 106484; 5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
SMILES NC1=NN2C(C)=CC(C)=NC2=N1

Description

5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine features a fused triazolopyrimidine core with methyl groups at the 5- and 7-positions, enhancing electronic density and steric profile. This scaffold serves as a rigid, electron-rich heterocyclic building block for medicinal chemistry applications, offering improved metabolic stability and target engagement in kinase inhibitor design.

Application

5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of biologically active scaffolds. Its core structure exhibits enhanced metabolic stability and favorable solubility, facilitating downstream functionalization via standard amine coupling reactions. The molecule demonstrates robust bench stability and compatibility with common protecting group strategies, supporting efficient synthesis of complex targets in drug discovery campaigns.

Synthesis

Route1
- In-stock
  
  1455-77-2
- 123-54-6
- ~74%
- In-stock
  
  7135-02-6
References
- Bishop, Brian C.; Marley, Hugh; Preston, Peter N.; Wright, Stanley H. B. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 11 p. 1527 - 1532
Route2
- 123-54-6
- ~%
- In-stock
  
  7135-02-6
References
- Astakhov; Chernyshev Chemistry of Heterocyclic Compounds, 2012 , vol. 48, # 9 p. 1417 - 1419 Khim. Geterotsikl. Soedin., 2012 , vol. 9, p. 1519 - 1521,3

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P363-P405-P501

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Computational Chemistry Data

TPSA 69.1
LogP 0.32334
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Triazole compounds

Key Words

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5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylamine

CAS No. 7135-02-6

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