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CS-W001157 4
Total: USD 88.00

7-Fluorooxindole

  • CAS No. 71294-03-6

  • Cat. No. CS-W002915
  • Purity≥95%
  • MDL No.MFCD02179608

*For research and further manufacturing use only, not for direct human use.

7-Fluorooxindole|CS-W002915

Structure of 71294-03-6

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General Information

  • CAS No. 71294-03-6
  • Cat. No. CS-W002915
  • Purity ≥95%
  • MDL No. MFCD02179608
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆FNO
  • Molecular Weight 151.14
  • Synonym(s) 7-fluoroindolin-2-one
  • SMILES O=C1NC2=C(C=CC=C2F)C1

Description

7-Fluorooxindole features a fluorinated aromatic ring that enhances metabolic stability and modulates electronic properties for use in medicinal chemistry. This bench-stable heterocycle integrates readily into kinase inhibitors and other bioactive scaffolds, offering improved membrane permeability and target engagement through strategic fluorine placement.

Application

7-Fluorooxindole serves as a valuable building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization at the C3 position. Its fluorinated aromatic ring enhances metabolic stability and modulates electronic properties, while the oxindole core provides a rigid scaffold for target engagement. The compound exhibits excellent bench stability and compatibility with common coupling reactions, facilitating efficient synthesis of kinase inhibitors and other pharmaceutical candidates.

Synthesis

  • Route1

    References

    • Wyeth Patent: US2006/9509 A1, 2006 ; Location in patent: Page/Page column 9 ; US 20060009509 A1
  • Route2
    • (2-Fluoro-6-nitro-phenyl)-acetic acid|CS-0341004
      136916-19-3
    • ~82%
    • In-stock
      7-Fluorooxindole|CS-W002915
      71294-03-6

    References

    • Wyeth Patent: US2007/72897 A1, 2007 ; Location in patent: Page/Page column 64; 68 ;
  • Route3

    References

    • Wyeth Patent: US2007/27327 A1, 2007 ; Location in patent: Page/Page column 8; 10 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P301+P310-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.3203
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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