2-Methyl-1-(piperazin-1-yl)propan-1-one

Name: 2-Methyl-1-(piperazin-1-yl)propan-1-one
Brand: ChemScene
Availability: InStock
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CAS No. 71260-16-7
Cat. No. CS-0124433
Purity≥97%
MDL No.MFCD04973344

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Methyl-1-(piperazin-1-yl)propan-1-one|CS-0124433

Structure of 71260-16-7

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General Information

CAS No. 71260-16-7
Cat. No. CS-0124433
Purity ≥97%
MDL No. MFCD04973344
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₆N₂O
Molecular Weight 156.23
Synonym(s) 1-(2-METHYLPROPANOYL)-PIPERAZINE
SMILES CC(C)C(N1CCNCC1)=O

Description

2-Methyl-1-(piperazin-1-yl)propan-1-one features a reactive ketone group flanked by a sterically hindered methyl substituent and a piperazine ring, enabling efficient conjugation in synthetic transformations. This bench-stable scaffold integrates readily into bioactive molecule design, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

2-Methyl-1-(piperazin-1-yl)propan-1-one serves as a versatile synthetic building block for medicinal chemistry and heterocyclic synthesis. Its α-ketoamide functionality enables direct incorporation into peptidomimetics and bioactive scaffolds via nucleophilic addition or condensation reactions. The piperazine moiety provides enhanced solubility and hydrogen-bonding capacity, while the methyl-substituted ketone offers steric control and metabolic stability. This compound demonstrates bench stability, compatibility with standard purification methods, and broad functional group tolerance in multi-step syntheses.

Synthesis

Route1
- 414910-16-0
- ~99%
- In-stock
  
  71260-16-7
References
- BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel Patent: WO2011/130661 A1, 2011 ; Location in patent: Page/Page column 98; 106 ;
Route2
- 349130-22-9
- ~%
- In-stock
  
  71260-16-7
References
- ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2004/41829 A1, 2004 ; Location in patent: Page 74 ; WO 2004/041829 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

TPSA 32.34
LogP 0.0742
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Key Words

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2-Methyl-1-(piperazin-1-yl)propan-1-one

CAS No. 71260-16-7

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