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CS-W001157 4
Total: USD 88.00

Pyrrole-3-carboxaldehyde

  • CAS No. 7126-39-8

  • Cat. No. CS-D1061
  • Purity≥97%
  • MDL No.MFCD03426733

*For research and further manufacturing use only, not for direct human use.

Pyrrole-3-carboxaldehyde|CS-D1061

Structure of 7126-39-8

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General Information

  • CAS No. 7126-39-8
  • Cat. No. CS-D1061
  • Purity ≥97%
  • MDL No. MFCD03426733
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO
  • Molecular Weight 95.10
  • Synonym(s) 3-Formylpyrrole
  • SMILES O=CC1=CNC=C1

Description

Pyrrole-3-carboxaldehyde features a reactive aldehyde group positioned at the 3-position of the pyrrole ring, enabling direct integration into condensation reactions and heterocyclic syntheses. This bench-stable, moisture-tolerant reagent facilitates efficient construction of functionalized polycyclic architectures in medicinal chemistry and materials science applications.

Application

Pyrrole-3-carboxaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized aromatic systems. Its aldehyde functionality facilitates nucleophilic additions, condensations, and transition-metal-catalyzed couplings, while the pyrrole ring provides inherent electronic modulation. Bench-stable and compatible with common protecting group strategies, it functions effectively in multistep syntheses targeting pharmaceutical intermediates and agrochemicals.

Synthesis

  • Route1
    • N-((1H-Pyrrol-3-yl)methylene)-N-methylmethanaminium chloride|CS-0874008
      117067-97-7
    • ~68%
    • In-stock
      Pyrrole-3-carboxaldehyde|CS-D1061
      7126-39-8

    References

    • Bray, Brian L.; Mathies, Peter H.; Naef, Reto; Solas, Dennis R.; Tidwell, Thomas T.; et al. Journal of Organic Chemistry, 1990 , vol. 55, # 26 p. 6317 - 6328
  • Route2
    • null|null
      3724-43-4
    • ~39%
    • In-stock
      Pyrrole-3-carboxaldehyde|CS-D1061
      7126-39-8

    References

    • Takeda Pharmaceutical Company Limited Patent: US2007/60623 A1, 2007 ; Location in patent: Page/Page column 37 ;
  • Route3
    • null|null
      35302-95-5
    • ~67%
    • In-stock
      Pyrrole-3-carboxaldehyde|CS-D1061
      7126-39-8

    References

    • Garrido, Daniel O. A.; Buldain, Graciela; Ojea, Maria I.; Frydman, Benjamin Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 403 - 407

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   0.8272
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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