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Structure of 71027-02-6
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4,4,4-Trifluorocrotonic acid features a conjugated enoic system bearing three fluorine atoms at the terminal carbon, imparting strong electron-withdrawing character. This configuration enhances reactivity in Michael additions and enables direct incorporation into fluorinated building blocks for medicinal chemistry applications. The molecule exhibits enhanced metabolic stability compared to non-fluorinated analogs.
4,4,4-Trifluorocrotonic acid serves as a valuable building block in synthetic organic chemistry, enabling the construction of fluorinated heterocycles and bioactive scaffolds. Its conjugated enoic acid functionality facilitates nucleophilic addition, Michael reactions, and decarboxylative transformations under mild conditions. The trifluoromethyl group enhances metabolic stability and modulates electronic properties, making it useful in medicinal chemistry. Bench-stable and readily purified by recrystallization, it functions efficiently in standard coupling protocols and offers predictable reactivity for scalable synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: