Lot numbers can be found on the outside label of a product:
2-Oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
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CAS No. 70639-77-9
- Cat. No. CS-W005449
- Purity≥98%
- MDL No.MFCD08271842
*For research and further manufacturing use only, not for direct human use.
Structure of 70639-77-9
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General Information
- CAS No. 70639-77-9
- Cat. No. CS-W005449
- Purity ≥98%
- MDL No. MFCD08271842
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₉NO₃
- Molecular Weight 191.18
- Synonym(s) None
- SMILES O=C2CCC1=CC(=CC=C1N2)C(=O)O
Description
This tetrahydroquinoline derivative features a fused bicyclic core with a carboxylic acid at the 6-position and a ketone at the 2-position, enabling direct integration into bioactive molecule scaffolds. The electron-deficient quinoline ring facilitates nucleophilic addition reactions, while the carboxylic acid group supports conjugation via amide or ester linkages under standard conditions.
Application
2-Oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid serves as a versatile scaffold for medicinal chemistry and heterocyclic synthesis, enabling efficient access to quinoline-based pharmacophores. Its carboxylic acid functionality facilitates derivatization via amide coupling, esterification, or decarboxylation protocols. The molecule exhibits bench stability and tolerates common functional groups, supporting its use in modular library construction and targeted synthesis of bioactive compounds.
Synthesis
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Route1
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In-stock
3279-90-1 - ~%
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In-stock
70639-77-9
References
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US2004/122001 A1, ; US 20040122001 A1
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Route2
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83734-39-8 - ~%
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In-stock
70639-77-9
References
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Chemical and Pharmaceutical Bulletin, , vol. 34, # 2 p. 682 - 693
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Route3
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In-stock
61122-82-5 - ~%
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In-stock
70639-77-9
References
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Chemical and Pharmaceutical Bulletin, , vol. 34, # 2 p. 682 - 693
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 66.4
- LogP 1.2695
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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