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CS-W001157 4
Total: USD 88.00

(E)-Ethyl 3-(pyridin-2-yl)acrylate

  • CAS No. 70526-11-3

  • Cat. No. CS-0036494
  • Molecule weight177.20
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(E)-Ethyl 3-(pyridin-2-yl)acrylate|CS-0036494

Structure of 70526-11-3

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General Information

  • CAS No. 70526-11-3
  • Cat. No. CS-0036494
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₂
  • Molecular Weight 177.20
  • Synonym(s) trans-3-(pyridin-2-yl)-acrylic acid ethyl ester
  • SMILES CCOC(=O)/C=C/C1=CC=CC=N1

Description

(E)-Ethyl 3-(pyridin-2-yl)acrylate features a conjugated enoate system linked to a pyridine heterocycle, enabling efficient integration into cross-coupling and cycloaddition workflows. The extended π-system enhances reactivity in transition-metal-catalyzed processes, while the ethyl ester facilitates downstream derivatization. This bench-stable, moisture-tolerant acrylate serves as a key building block for bioactive heterocycles and functional materials.

Application

(E)-Ethyl 3-(pyridin-2-yl)acrylate serves as a versatile synthetic building block in organic and medicinal chemistry, enabling efficient construction of functionalized α,β-unsaturated esters. Its conjugated system facilitates Diels-Alder reactions, Michael additions, and palladium-catalyzed cross-couplings. The pyridyl moiety provides orthogonal reactivity and enhanced solubility, while the (E)-configuration ensures predictable stereochemical outcomes. Bench-stable and readily purified by column chromatography, it functions as a key intermediate in heterocyclic synthesis and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P280-P304+P340

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6579
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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