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CS-W001157 4
Total: USD 88.00

3,5-Dimethoxybenzyl alcohol

  • CAS No. 705-76-0

  • Cat. No. CS-W017809
  • Purity≥98%
  • MDL No.MFCD00004641

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethoxybenzyl alcohol|CS-W017809

Structure of 705-76-0

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General Information

  • CAS No. 705-76-0
  • Cat. No. CS-W017809
  • Purity ≥98%
  • MDL No. MFCD00004641
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂O₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES COC1=CC(OC)=CC(CO)=C1

Description

3,5-Dimethoxybenzyl alcohol features a benzyl backbone adorned with two methoxy groups at the 3 and 5 positions, conferring enhanced solubility and stability. This electron-rich scaffold serves as a robust building block in synthetic routes requiring steric protection or directed functionalization. The hydroxymethyl group enables facile derivatization, supporting its use in medicinal chemistry and materials synthesis under standard conditions.

Application

3,5-Dimethoxybenzyl alcohol serves as a versatile building block in medicinal chemistry and natural product synthesis, offering enhanced solubility and metabolic stability through its ortho-dimethoxy substitution. The primary alcohol facilitates straightforward derivatization via esterification, etherification, or coupling reactions, while the protected aromatic ring resists oxidation under standard conditions. Its bench-stable, crystalline nature enables reliable handling and purification, making it a practical choice for constructing complex scaffolds and bioactive molecules.

Synthesis

  • Route1

    References

    • Meier, Herbert; Dullweber, Uta Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1191 - 1194
  • Route2

    References

    • Parihar, Swati; Kumar, Amit; Chaturvedi, Amit K.; Sachan, Naresh Kumar; Luqman, Suaib; Changkija, Bendangla; Manohar, Murli; Prakash, Om; Chanda; Khan, Feroz; Chanotiya; Shanker, Karuna; Dwivedi, Anila; Konwar, Rituraj; Negi, Arvind S. Journal of Steroid Biochemistry and Molecular Biology, 2013 , vol. 137, p. 332 - 344
  • Route3

    References

    • Jana, Nandan; Nanda, Samik European Journal of Organic Chemistry, 2012 , # 23 p. 4313 - 4320

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P301+P310-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   1.1961
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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