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CS-W001157 4
Total: USD 88.00

((Trifluoromethyl)sulfinyl)benzene

  • CAS No. 703-18-4

  • Cat. No. CS-0134178
  • Molecule weight194.17
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

((Trifluoromethyl)sulfinyl)benzene|CS-0134178

Structure of 703-18-4

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General Information

  • CAS No. 703-18-4
  • Cat. No. CS-0134178
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₃OS
  • Molecular Weight 194.17
  • Synonym(s) Phenyl trifluoromethyl sulfoxide
  • SMILES O=S(C1=CC=CC=C1)C(F)(F)F

Description

((Trifluoromethyl)sulfinyl)benzene features a highly polar sulfinyl group attached to a trifluoromethyl-substituted aromatic ring, delivering exceptional electron-withdrawing character and enhanced stability under ambient conditions. This combination enables direct incorporation into complex molecular architectures, particularly in pharmaceutical intermediates and functional materials requiring robust, fluorinated building blocks.

Application

((Trifluoromethyl)sulfinyl)benzene serves as a versatile building block in synthetic organic chemistry, enabling the introduction of the trifluoromethylsulfinyl group—a potent electron-withdrawing and sterically distinct moiety—into complex molecular architectures. It functions reliably in nucleophilic substitution and transition-metal-catalyzed coupling reactions, offering enhanced stability and ease of purification compared to analogous sulfenylating agents. Its utility is well-established in the synthesis of fluorinated pharmaceutical intermediates and agrochemical scaffolds.

Synthesis

  • Route1

    References

    • Tang, Ri-Yuan; Zhong, Ping; Lin, Qiu-Lian Journal of Fluorine Chemistry, 2007 , vol. 128, # 6 p. 636 - 640
  • Route2

    References

    • Singh, Rajendra P.; Cao, Ganfeng; Kirchmeier, Robert L.; Shreeve, Jean'ne M. Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2873 - 2876
  • Route3
    • In-stock
      Sodium trifluoromethanesulfinate|CS-W004656
      2926-29-6
    • null|null
      71-43-2
    • ~49%
    • In-stock
      ((Trifluoromethyl)sulfinyl)benzene|CS-0134178
      703-18-4

    References

    • Magnier, Emmanuel; Blazejewski, Jean-Claude; Tordeux, Marc; Wakselman, Claude Angewandte Chemie - International Edition, 2006 , vol. 45, # 8 p. 1279 - 1282

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.314
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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