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Structure of 702641-04-1
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2-Iodo-5-(trifluoromethyl)benzoic acid features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability, while the iodine substituent enables facile cross-coupling reactions. This combination delivers a robust platform for constructing complex aromatic architectures in medicinal chemistry and materials science applications under standard conditions.
2-Iodo-5-(trifluoromethyl)benzoic acid serves as a versatile building block for Suzuki-Miyaura and Sonogashira coupling reactions, enabling efficient construction of biaryl and alkynyl scaffolds. The iodine moiety offers high reactivity under palladium catalysis, while the trifluoromethyl group enhances metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and compatible with common protecting groups, it facilitates straightforward purification and integration into complex molecular architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: