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CS-W001157 4
Total: USD 88.00

Trifluridine

  • CAS No. 70-00-8

  • Cat. No. CS-1602
  • Purity≥98%
  • MDL No.MFCD00006534

*For research and further manufacturing use only, not for direct human use.

Trifluridine|CS-1602

Structure of 70-00-8

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General Information

  • CAS No. 70-00-8
  • Cat. No. CS-1602
  • Purity ≥98%
  • MDL No. MFCD00006534
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁F₃N₂O₅
  • Molecular Weight 296.20
  • Synonym(s) Trifluorothymidine; 5-Trifluorothymidine; TFT
  • SMILES O[C@H]1C[C@H](N2C(NC(C(C(F)(F)F)=C2)=O)=O)O[C@@H]1CO

Description

.

Application

Trifluridine serves as a potent antiviral nucleoside analog, functioning as a thymidine derivative with trifluoromethyl substitution that enhances cellular uptake and resistance to enzymatic degradation. It enables efficient incorporation into viral DNA during replication, disrupting synthesis through chain termination. The compound exhibits robust bench stability and is widely used in nucleoside-based synthetic pathways for antiviral research, particularly in the development of topical treatments for herpes simplex virus infections.

Synthesis

  • Route1
    • null|null
      2314-97-8
    • In-stock
      2'-Deoxyuridine|CS-W019820
      951-78-0
    • ~59%
    • In-stock
      Trifluridine|CS-1602
      70-00-8

    References

    • Tosoh Corporation; Tosoh F- Tech Inc.; SAGAMI CHEMICAL RESEARCH CENTER Patent: EP1947092 A1, 2008 ; Location in patent: Page/Page column 43-44 ;
  • Route2
    • null|null
      65499-42-5
    • ~96%
    • In-stock
      Trifluridine|CS-1602
      70-00-8

    References

    • Kumar, Vineet; Malhotra, Sanjay V. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5640 - 5642
  • Route3

    References

    • Fang, Zhongxue; Ning, Yongquan; Mi, Pengbing; Liao, Peiqiu; Bi, Xihe Organic Letters, 2014 , vol. 16, # 5 p. 1522 - 1525

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H341-H351-H361
Precautionary Statements : P280-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   104.55
  • LogP   -0.8039
  • H_Acceptors   6
  • H_Donors   3
  • Rotatable_Bonds   2

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