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CS-W001157 4
Total: USD 88.00

6-Amino-1-indanone

  • CAS No. 69975-65-1

  • Cat. No. CS-W020513
  • Purity≥95%
  • MDL No.MFCD00100747

*For research and further manufacturing use only, not for direct human use.

6-Amino-1-indanone|CS-W020513

Structure of 69975-65-1

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General Information

  • CAS No. 69975-65-1
  • Cat. No. CS-W020513
  • Purity ≥95%
  • MDL No. MFCD00100747
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉NO
  • Molecular Weight None
  • Synonym(s) 6-Aminoindanone
  • SMILES O=C1CCC2=C1C=C(N)C=C2

Description

6-Amino-1-indanone features a fused bicyclic core with an amino group at the 6-position, delivering enhanced electron density and reactivity. This bench-stable scaffold integrates readily into pharmaceutical intermediates and functional materials, offering improved solubility in polar solvents and compatibility with standard synthetic protocols.

Application

6-Amino-1-indanone serves as a versatile building block in medicinal chemistry, enabling the synthesis of indanone-based scaffolds through standard functional group transformations. Its amino group facilitates nucleophilic substitution, amidation, and coupling reactions, while the ketone moiety supports enolate formation and reductive amination. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it valuable for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • DECIPHERA PHARMACEUTICALS, LLC Patent: WO2006/71940 A2, 2006 ; Location in patent: Page/Page column 396 ; WO 2006/071940 A2
  • Route2

    References

    • Comess, Kenneth M.; Erickson, Scott A.; Henkin, Jack; Kalvin, Douglas M.; Kawai, Megumi; Kim, Ki H.; BaMaung, Nwe Y.; Park, Chang Hoon; Sheppard, George S.; Vasudevan, Anil; Wang, Jieyi; Barnes, David M.; Fidanze, Steve D.; Kolaczkowski, Lawrence; Mantei, Robert A.; Park, David C.; Sanders, William J.; Tedrow, Jason S.; Wang, Gary T. Patent: US2004/167128 A1, 2004 ; Location in patent: Page 39 ;
  • Route3
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      85515-20-4
    • ~%
    • In-stock
      6-Amino-1-indanone|CS-W020513
      69975-65-1

    References

    • WO2006/20070 A2, ; Page/Page column 51-52 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.3977
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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