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CS-W001157 4
Total: USD 88.00

6-Chloro-1H-indazole

  • CAS No. 698-25-9

  • Cat. No. CS-W005017
  • Purity≥97%
  • MDL No.MFCD07774234

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1H-indazole|CS-W005017

Structure of 698-25-9

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General Information

  • CAS No. 698-25-9
  • Cat. No. CS-W005017
  • Purity ≥97%
  • MDL No. MFCD07774234
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClN₂
  • Molecular Weight 152.58
  • Synonym(s) 6-CHLOROINDAZOLE
  • SMILES ClC1=CC2=C(C=NN2)C=C1

Description

6-Chloro-1H-indazole is a heterocyclic compound featuring a chlorine substituent at the 6-position of the indazole core. This electron-deficient scaffold integrates readily into medicinal chemistry libraries, offering enhanced metabolic stability and improved binding affinity in kinase inhibitors and targeted therapeutics.

Application

6-Chloro-1H-indazole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling reactions. Its stability under standard reaction conditions and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds. The chlorine substituent facilitates nucleophilic substitution and further derivatization, supporting efficient access to targeted molecular architectures in API development.

Synthesis

  • Route1

    References

    • WO2011/149921 A1, ; Page/Page column 78 ;
  • Route2
    • null|null
      95-79-4
    • ~%
    • In-stock
      6-Chloro-1H-indazole|CS-W005017
      698-25-9

    References

    • Bulletin of the Chemical Society of Japan, , vol. 58, # 1 p. 309 - 315
  • Route3
    • null|null
      108-24-7
    • null|null
      95-79-4
    • ~%
    • In-stock
      6-Chloro-1H-indazole|CS-W005017
      698-25-9

    References

    • WO2011/149921 A1, ; Page/Page column 77; 78 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.2163
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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