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CS-W001157 4
Total: USD 88.00

8-Bromoadenine

  • CAS No. 6974-78-3

  • Cat. No. CS-0112888
  • Purity≥97%
  • MDL No.MFCD00082518

*For research and further manufacturing use only, not for direct human use.

8-Bromoadenine|CS-0112888

Structure of 6974-78-3

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General Information

  • CAS No. 6974-78-3
  • Cat. No. CS-0112888
  • Purity ≥97%
  • MDL No. MFCD00082518
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrN₅
  • Molecular Weight 214.02
  • Synonym(s) 8-Bromo-9H-purin-6-amine
  • SMILES BrC1=NC2=C(N1)C(N)=NC=N2

Description

8-Bromoadenine serves as a key purine derivative for site-specific modification in nucleic acid chemistry. This brominated analog integrates readily into oligonucleotide synthesis, enabling precise functionalization at the C8 position. The halogenated moiety enhances reactivity in palladium-catalyzed coupling reactions, facilitating conjugation with fluorophores, biotin, or other molecular probes. Its stability under standard synthetic conditions supports reliable incorporation during solid-phase synthesis workflows.

Synthesis

  • Route1
    • null|null
      66224-66-6
    • ~74%
    • In-stock
      8-Bromoadenine|CS-0112888
      6974-78-3

    References

    • US2008/234297 A1, ; Page/Page column 33; 38 ; US 20080234297 A1
  • Route2

    References

    • Tetrahedron Letters, , vol. 24, # 34 p. 3571 - 3572
  • Route3

    References

    • Tetrahedron Letters, , vol. 35, # 28 p. 4989 - 4990

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   80.48
  • LogP   0.6976
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

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