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3-(Chloromethyl)-1H-pyrazole hydrochloride

  • CAS No. 69658-97-5

  • Cat. No. CS-0437008
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Chloromethyl)-1H-pyrazole hydrochloride|CS-0437008

Structure of 69658-97-5

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General Information

  • CAS No. 69658-97-5
  • Cat. No. CS-0437008
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆Cl₂N₂
  • Molecular Weight 153.01
  • Synonym(s) 3-(CHLOROMETHYL)-1H-PYRAZOLE
  • SMILES ClCC1=NNC=C1.Cl

Description

3-(Chloromethyl)-1H-pyrazole hydrochloride is a bench-stable, moisture-tolerant heterocyclic building block featuring a reactive chloromethyl group. This functionalized pyrazole integrates readily into medicinal chemistry scaffolds, enabling efficient coupling reactions via nucleophilic substitution. The hydrochloride salt enhances solubility and handling in aqueous or polar organic media.

Application

3-(Chloromethyl)-1H-pyrazole hydrochloride serves as a versatile synthetic building block for pyrazole-based scaffolds, enabling efficient incorporation of a reactive chloromethyl group at the 3-position. Its bench-stable hydrochloride salt form enhances handling and storage, while the electrophilic chloride facilitates nucleophilic substitution reactions with amines, thiols, and heterocycles. The compound functions reliably in standard functionalization workflows, supporting the construction of bioactive molecules and pharmaceutical intermediates with predictable reactivity.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.5703
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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